Epigenetic mechanisms regulate multiple aspects of normal development and are often misregulated in aging and disease. We study the basic mechanisms of epigenetic regulation using a combination of mouse genetics, cell biology, biochemical and multi-omics approaches.
Recent News
ERV-derived cryptic enhancers
Our data show that histone methyltransferase SETDB1 is critical for preventing transcription…
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G4 structures in SVA retrotransposons
G-quadruplexes (G4s) are non-canonical nucleic acid structures that form in guanine-rich regions…
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Changed metabolism affects TF activity in T cell lymphoma
PD-1 is a critical tumor suppressor in T cells. Loss of PD-1…
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Groh S, Milton AV, Marinelli LK, Sickinger CV, Russo A, Bollig H, de Almeida GP, Schmidt A, Forné I, Imhof A, Schotta G. Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation. Nat Commun. 2021 Oct 14;12(1):5996.
Cernilogar FM, Hasenöder S, Wang Z, Scheibner K, Burtscher I, Sterr M, Smialowski P, Groh S, Evenroed IM, Gilfillan GD, Lickert H, Schotta G. Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2. Nucleic Acids Res. 2019 Sep 26;47(17):9069-9086.
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Research topics
- Control of endogenous retroviruses
- Heterochromatin silencing mechanisms
- Transcription factor biology
- Epigenetic alterations in cancer
Team
Prof. Dr. Gunnar Schotta
gunnar.schotta@bmc.med.lmu.de
Dr. Filippo Cernilogar
senior scientist
Li Li
PhD Student
Angela Russo
PhD Student
Eugenio Fergola
PhD Student
Heike Bollig
Technician
The Schotta Lab 