G-quadruplexes (G4s) are non-canonical nucleic acid structures that form in guanine-rich regions and play a significant role in regulating the TAF1 gene in X-linked dystonia parkinsonism (XDP). In this condition, a retrotransposon called SVA is inserted into intron 32 of the TAF1 gene, promoting the formation of stable G4s. These G4 structures hinder the proper

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PD-1 is a critical tumor suppressor in T cells. Loss of PD-1 in T cell lymphomas results in higher activity of ATP citrate lyase and higer levels of extramitochondrial acetyl-CoA. This allows hyperacetylation of H3K27 in the context of AP-1 transcription factors. Pharmacological inhibition of ATP citrate lyase can counteract aberrant AP-1 activity and is

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